《英文msh詞典》Isaacs-Mertens Syndrome
[入口詞] Isaacs-Mertens Syndrome
[主題詞] Isaacs Syndrome
[英文釋義] A rare neuromuscular disorder with onset usually in late childhood or early adulthood,characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al.,Principles of Neurology,6th ed,p1491)